This new tick and flea option for dogs contains the patented active ingredient lotilaner, which targets the nervous system receptors of ticks and fleas, not dogs.1
Credelio is a small, tasty2 chewable tablet approved for puppies and dogs eight weeks of age and older and 4.4 pounds and greater. Credelio protects against ticks of common concern across the U.S.: lone star tick (Amblyomma americanum), American dog tick (Dermacentor variabilis), black-legged tick (Ixodes scapularis) and brown dog tick (Rhipicephalus sanguineus), as well as fleas (Ctenocephalides felis).
Easy on Dogs
In a field study, 100 percent of Credelio tablets were administered successfully and dogs accepted 94 percent of them when offered by hand, in an empty bowl, or with food.2 Credelio is also well accepted by a broad range of dog breeds, including toy dogs such as Chihuahuas and Yorkshire terriers.2-5 Further, Credelio offers the reassurance of a product that is suitable for puppies as young as eight weeks of age.
Tough on Ticks and Fleas
Credelio’s active ingredient—lotilaner—circulates in the dog’s blood stream, targeting the receptors of ticks and fleas when they bite the dog. In clinical studies, Credelio killed 100 percent of fleas within 12 hours for the entire month.6Credelio starts to kill ticks and fleas in just 4 hours6,7. This fast initial onset of action provides rapid relief from existing ticks. Credelio’s sustained speed-of-kill throughout the dosing period provides protection from newly-acquired ticks. Credelio works fast because it is absorbed rapidly and achieves peak plasma levels quickly. When given with food, Credelio reaches peak blood levels within 2 hours of dosing.8
Indications
Credelio kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick) and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater.
Important Safety Information
The safe use of Credelio in breeding, pregnant, or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures. The most frequently reported adverse reactions are weight loss, elevated blood urea nitrogen, excessive urination, and diarrhea. See package insert for full safety information.
References
1Rufener, L. et al. 2017. “The novel isoxazoline ectoparasiticide lotilaner (Credelio®): a noncompetitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls).” Parasites & Vectors. 10:530.
2Karadzovska, D. et al. 2017. “A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (Credelio®) in eliminating fleas in client-owned dogs in the USA.” Parasites & Vectors. 10:528.
3Cavalleri, D. et al. 2017. “A randomized, blinded, controlled field study to assess the efficacy and safety of lotilaner tablets (Credelio®) in controlling fleas in client-owned dogs in European countries.” Parasites & Vectors. 10:526.
4Cavalleri, D. et al. 2017. “A randomized, controlled study to assess the efficacy and safety of lotilaner (Credelio®) in controlling ticks in client-owned dogs in Europe.” Parasites & Vectors. 10:531.
5Elanco Animal Health. Data on File.
6Cavalleri, D. et al. 2017. “Assessment of the speed of flea kill of lotilaner (Credelio®) throughout the month following oral administration to dogs.” Parasites & Vectors. 10:529.
7Murphy, M. et al. 2017. “Laboratory evaluation of the speed of kill of lotilaner (Credelio®) against Ixodes ricinus ticks on dogs.” Parasites and Vectors. 10:541.
8Toutain C. et al. 2017. “The intravenous and oral pharmacokinetics of lotilaner in dogs.” Parasites & Vectors. 10:522.
Source: PR Newswire
