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Selected Milestone Events In Heartworm Disease

1963 Recommendations for the use of sodium caparsolate as an adulticide
1967 Recommendations for the use of DEC as a preventative
1969 Epidemiological surveys and heartworm distribution maps
1974 Began series of papers that led to a better understanding of feline heartworm disease
1974 Founding of American Heartworm Society at the Fourth Heartworm Symposium
1986 The use of ELISA antigen-detection tests for the diagnosis of canine heartworm disease
1987 Introduction of ivermectin as an oral monthly preventative
1991 Introduction of milbemycin as an oral monthly preventative
1993 The first report of “”safety-net”” (reach-back) activity of macrocyclic lactones
1995 Presentation calling attention to lack of compliance (clinic) of heartworm preventative
1995 The role of PIMs on the pathophysiology of feline heartworm disease
1995 The use of immunochromatographic antigen-detection tests for the diagnosis of canine heartworm disease
1997 Introduction of ivermectin for cats as an oral monthly preventative
1998 The use of antibody-detection test kits for the diagnosis of feline heartworm disease
1998 The adulticidal activity of monthly prophylactic doses of ivermectin
1999 Introduction of selamectin as a monthly topical preventative
2000-2004 The potential role of Wolbachia in the pathogenesis of canine and feline heartworm disease
2001 Introduction of long-acting moxidectin as an injectable
2001 American Heartworm Society begins collaboration with the Morris Animal Foundation to manage research funds for both feline and canine heartworm studies
2004 A comprehensive review of the zoonotic picture
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